Simulation of blood flow past distal arteriovenous-graft anastomosis with intimal hyperplasia

Late-stage kidney disease patients have to rely on hemodialysis for the maintenance of their regular lives. Arteriovenous graft (AVG) is one commonly used devices dialysis. However, this artificially created shunt may get clotted and eventually causes dialysis fail. The culprit behind AVG clotting failure intimal hyperplasia (IH), gradual thickening vein-wall in vicinity blood vessel-graft conjunctions. mechanism IH not well understood despite extensive studies. In work, we investigate effects development, including its location severity flow force fields distal anastomosis using computational fluid dynamics. stenosis due modeled shape a Gaussian function with two free parameters. as viscous incompressible fluid, (pulsatile) governed by Navier–Stokes equations which are numerically solved lattice Boltzmann model (D3Q19). fluid-structure interaction immersed boundary framework. Our results show that has most significant influences wall shear stress, wall-normal axial oscillating index. pulsatility do pronounced fields. indicate progression tends exacerbate accelerate closure vein lumen, hence failure.